Review

The management of persistent pulmonary hypertension of the newborn: A review

Lizel Georgi Lloyd, Johan Smith

Abstract


The first literary reference to persistent pulmonary hypertension (PH) of the newborn (PPHN) can be found in 1969 by Gersony et al., who described it as persistence of physiologic characteristics of the fetal circulation in the absence of disease. Defined as a failure of normal circulatory transition at birth, or more specifically as failure of the pulmonary vasculature to relax after birth, with continued shunting of non-oxygenated blood into the systemic circulation via fetal channels (ductus arteriosus and foramen ovale), it remains a challenging neonatal emergency to manage. Term and nearterm infants are most commonly affected, but PPHN can occur in premature infants.


Authors' affiliations

Lizel Georgi Lloyd, Division of Neonatology, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children’s Hospital, Cape Town, South Africa

Johan Smith, Division of Neonatology, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children’s Hospital, Cape Town, South Africa

Full Text

PDF (154KB)

Keywords

Persistent pulmonary hypertension

Cite this article

South African Journal of Child Health 2016;10(4):194. DOI:10.7196/SAJCH.2016.v10i4.1145

Article History

Date submitted: 2016-03-03
Date published: 2016-12-14

Article Views

Abstract views: 1351
Full text views: 931

Comments on this article

*Read our policy for posting comments here