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Neonatal sepsis: Highlighting the principles of diagnosis and management

M Coetzee, N Mbowane, T de Witt

Abstract


Neonatal sepsis is a clinical syndrome consisting of nonspecific symptoms and signs of infection, accompanied by a bacteraemia in the first 28 days of life. The risk of neonatal sepsis and death increases with decreasing birth weight and gestational age. South African data have reported the overall incidence of neonatal sepsis to be 8.5 - 10%, with late-onset sepsis accounting for most of these infections. The diagnosis of neonatal sepsis is not always straightforward, and the initiation and continuation of antimicrobials in these situations relies on good clinical judgment. The need for empirical antimicrobials is driven by the existence of risk factors for early-onset sepsis and clinical symptoms and signs of late-onset sepsis. Antimicrobial stewardship programmes should be in place to guide clinicians to either stop, change, or continue antimicrobials. Institution-specific knowledge of the most common pathogens and the antimicrobial susceptibility pattern is important to prevent the emergence of further antimicrobial resistance.


Authors' affiliations

M Coetzee, Division of Neonatology, Department of Paediatrics and Child Health, School of Medicine, University of Pretoria, South Africa

N Mbowane, Division of Neonatology, Department of Paediatrics and Child Health, School of Medicine, University of Pretoria, South Africa

T de Witt, Division of Neonatology, Department of Paediatrics and Child Health, School of Medicine, University of Pretoria, South Africa

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Cite this article

South African Journal of Child Health 2017;11(2):99-103. DOI:10.7196/SAJCH.2017.v11i2.1244

Article History

Date submitted: 2017-07-05
Date published: 2017-07-05

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