Research

Prevalence of coeliac disease in children and adolescents with type 1 diabetes mellitus in a tertiary hospital in South Africa

M Karsas, A J Terblanche, T Kemp, J C van Dyk

Abstract


Background. International literature has shown the prevalence of coeliac disease (CD) in children and adolescents with diabetes to range from 1 - 10%. Prevalence rates in African countries are limited or unknown.

Objective. The objective was to describe the prevalence of CD in all children and adolescents with type 1 diabetes mellitus presenting to the paediatric and adult diabetic clinic at Steve Biko Academic Hospital, Pretoria, South Africa.

Method. A retrospective review of the files of all children and adolescents in the paediatric and adult diabetic clinic with type 1 diabetes mellitus between August 2016 and June 2019 was conducted. Children requiring screening and/or intestinal biopsies were also prospectively included during this period. The setting of this study was Steve Biko Academic Hospital, a tertiary referral centre, in Pretoria, South Africa. Coeliac screening included anti-deaminated gliadin antibodies and anti-tissue transglutaminase antibodies (both IgA and IgG). All biopsies were obtained by a paediatric gastroenterologist or an experienced paediatric surgeon.

Results. A total of 184 files were screened; 132 met inclusion criteria but only 108 patients in total had coeliac screening. Positive antibody screening for CD was found in 11 out of 108 patients (10.2%). Nine of the 11 serology-positive patients had biopsies performed. Out of the nine biopsies, two (22.2%) were positive for CD based on the Marsh-Oberhuber classification.

Conclusion. This study found a prevalence of serology-positive CD in our local population of South African children with type 1 diabetes mellitus of 10.2%, while the prevalence of biopsy-confirmed CD was found to be 1.9%.


Authors' affiliations

M Karsas, Department of Paediatric Endocrinology, University of Pretoria, South Africa; University of Pretoria Diabetes Research Centre, South Africa

A J Terblanche, Department of Paediatric Gastroenterology, University of Pretoria, South Africa

T Kemp, Department of Paediatric Endocrinology, University of Pretoria, South Africa; University of Pretoria Diabetes Research Centre, South Africa; Department of Endocrinology, University of Pretoria, South Africa

J C van Dyk, Department of Paediatric Endocrinology, University of Pretoria, South Africa

Full Text

PDF (218KB)

Cite this article

South African Journal of Child Health 2021;15(4):212.

Article History

Date submitted: 2022-02-02
Date published: 2022-02-02

Article Views

Abstract views: 959
Full text views: 492

Comments on this article

*Read our policy for posting comments here