Case Reports

Diffuse bony involvement in disseminated BCG disease in a patient with possible severe combined immune deficiency (SCID)

Nausheen Khan, Irma van de Werke, Farzanah Ismail


BCG (bacille Calmette-Guérin) vaccination is carried out worldwide to prevent tuberculosis. It is considered to be very effective and has an excellent safety profile, but complications do occur. These may range from erythema and abscess at the site of inoculation to extensive disseminated disease including regional and distant lymphadenopathy, lymphadenitis, musculoskeletal lesions and non-fatal and fatal disseminated infections, depending upon the immune status of the patient. Osteomyelitis is a rare but serious complication that may have a fatal outcome. We report a case of severe tuberculous osteomyelitis secondary to BCG vaccination in a child with possible severe combined immune deficiency.

Authors' affiliations

Nausheen Khan, University of Pretoria

Irma van de Werke, University of Pretoria

Farzanah Ismail, University of Pretoria

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Disseminated BCG, SCID, Immunodeficiency

Cite this article

South African Journal of Child Health 2010;4(4):116.

Article History

Date submitted: 2010-09-15
Date published: 2010-12-08

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