Trends in perinatal health indices in the Amajuba District, KwaZulu-Natal, South Africa, 1990 - 2012
1 Madadeni Hospital, Newcastle, South Africa
2 Department of Paediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu , Nigeria
T I Runsewe-Abiodun
Background. In order to address the high perinatal mortality rate, South Africa (SA) commenced a number of interventions from 1995. These included the abolition of user fees, basic antenatal care, on-the-spot diagnosis and treatment of syphilis, and the prevention of mother-to-child transmission of HIV. However, there is a dearth of information on the long-term effect of these programmes on perinatal indicators in district hospitals, where most births and deaths occur.
Objective. To determine the levels and trends in maternal and neonatal indicators in Amajuba District, KwaZulu-Natal Province, SA, and to ascertain the dynamics of these indicators vis-à-vis the transformation of healthcare in SA.
Methods. The study location was Madadeni Hospital and its nine feeder maternity clinics. Information pertaining to all deliveries and their outcome from these health facilities from 1990 to 2012 was extracted from the clinical registers. Data were analysed using SPSS version 15.0 (IBM, USA). Quantitative variables were summarised as means, while qualitative data were expressed as proportions and percentages. The trends for each outcome variable for the entire study period (1990 - 2012) were analysed and presented as line graphs and tables.
Results. There were 154 821 live births and 4 133 stillbirths from 1990 to 2012. The overall mean values for stillbirth rate, perinatal mortality rate, neonatal mortality rate and maternal mortality ratio were 26.3 (standard deviation 5.6), 40.9 (9.6), 16.8 (4.7) and 114 (56.6), respectively. There was a general improvement in all the perinatal health indices in the early 90s, followed by a general worsening until the early 2000s, after which a consistent decline was noted.
Conclusion. The perinatal health indices in Amajuba District have followed a pattern similar to that found in the rest of SA: an increase during the late 90s to early 2000s, followed by a decline from the late second half of the first decade of this century.
S Afr J CH
Globally, each year there are 0.5 million maternal deaths, 2 million infants die within 24 hours and there are 2.6 million stillbirths. Almost all (99%) of these deaths occur in low- and middle-income countries,1 , 2 mainly as a result of scarcity of healthcare institutions; even where available, these facilities are typically overcrowded, understaffed and ill-equipped, resulting in poor-quality care.3 Thus, in order to achieve Millenium Development Goals 4 and 5,4 substantial improvements in delivery of healthcare services will be required. In order to address the issue of high perinatal mortality, South Africa (SA) implemented a number of interventions. These included the abolition of user fees, basic antenatal care, on-the-spot syphilis testing and treatment, and primary healthcare.5-9
Furthermore, in Amajuba District, the use of nasal continuous positive airway pressure commenced in 1996,10 antenatal care was transferred to clinics in 2000, the use of nevirapine for the prevention of mother-to-child transmission (PMTCT) of HIV started in 2003. The other major developments occurred in 2009: care centres became baby friendly, a six-bed kangaroo mother care (KMC) unit was established, ambulance services were upgraded and the care centres obtained the Council for Health Services Accreditation of SA (COHSASA).
The paradox is that despite these developments, national reports indicate that progress towards reducing neonatal and maternal deaths is disappointing, and by the middle of the decade 2000 - 2010, SA was one of the few countries in the world with rising mother and child mortality.3 , 11 , 12 As a result of considerable inequalities that still exist in SA with regard to access to quality healthcare,3 , 13 the relevance of national averages to Amajuba District is not clear.
In this study, we therefore set out to use
local information to evaluate services in Amajuba District. We
documented and analysed the level and trends in neonatal and
maternal health indicators, and examined them against the
backdrop of the ongoing transformation of healthcare in SA.
This was a retrospective, descriptive study involving delivery
of all babies of at least 500 g in the Madadeni Hospital and its
nine feeder maternity clinics. The study period spanned between
1990 and 2012.
Madadeni hospital is located in the Amajuba District, KwaZulu-Natal Province, SA. It provides the main maternal and neonatal services to mostly rural and semirural communities in Amajuba District. The hospital and its feeder maternity clinics serve a total population of 500 000 people.
For most of this study period (1990 - 2006), maternal and neonatal bed space remained unchanged in Madadeni Hospital, which provided district-level care. Service was rendered by 4 - 6 medical officers in obstetrics and 1 medical officer in the Special Care Baby Unit (SCBU).
Changes in care were limited to
increased use of prenatal steroids and magnesium sulphate, the
establishment of a four-bed high-care unit in 1996, and a
six-bed KMC unit in 2009. Between 1990 and 2009,
admission to the SCBU was flexible, but from 2010 to 2012,
only infants with strictly defined medical conditions were
Data were extracted from the clinical registers of Madadeni Hospital and the nine feeder maternity clinics in its catchment area for the period 1990 - 2012. Infant information retrieved included weight at birth, place of birth, presence of perinatal asphyxia (Apgar score <7 at 5 minutes), exposure to syphilis (mother Wassermann reaction positive), presence of meconium-stained liquor and chorioamnionitis (foul-smelling liquor and maternal pyrexia). For the purpose of this study, these parameters were used to determine risk of syphilis, meconium aspiration syndrome and bacterial septicaemia. The outcome of the babies was also noted.
For each mother-infant pair, presence
or absence of episiotomy, ruptured uterus and mode of delivery
were noted. From 2003, the HIV status and use of
antiretroviral (ARV) drugs for the PMTCT of HIV were also
medical manager gave permission for the study.
Data entry, validation and analysis were
done using SPSS version 15.0 (IBM, USA). Quantitative
variables were summarised as means (standard deviations
(SDs)), while qualitative data were expressed as proportions
and percentages. The trends for
each outcome variable for the entire study period (1990 - 2012) were analysed and presented as line
graphs and tables.
There were 158 954 births in
registered in Madadeni and its feeder maternity clinics
between 1990 and 2012, of which 154 821 (97.4%) were live and 4 133 (2.6%) were
stillbirths. Of the 158 954 deliveries in this series, 136 065
(85.6%), 20 664 (13%) and the
remaining 2 225 (1.4%) were in hospital, the clinics and
The overall mean (SD) values for stillbirth rate (SBR), perinatal mortality rate (PMR), neonatal mortality rate (NNMR) and maternal mortality ratio (MMR) were 26.3 (5.6), 40.9 (9.6), 16.8 (4.7) and 114 (56.6), respectively.
There was a general decrease in all the
perinatal health indices in the early 90s, followed by an
increase up until the early 2000s, after which a consistent
decline was noted (Table 1, Figs 1 and 2). It is noteworthy that
the decline in adverse perinatal outcomes was not smooth, as it
depicts peaks and troughs.
Fig. 1. Trends in perinatal health indices.
There was a substantial decline in the perinatal indices as exhibited by the percentage changes, especially the MMR (Table 2).
The overall low birth weight rate and the stillbirth:neonatal death rate were 9% and 4.3%, respectively. The perinatal care index ranged between 3.3 and 6.8, with an average of 4.9. It declined in the early 90s and thereafter climbed up for the next 10 years until the second descent commenced after 2007.
Feeder clinics utilisation
Over the study period, there was a
consistent drop in both the number of mothers seeking to give
birth in the clinics (potential clinic birth rate) and the
proportion of labouring women in the clinics who eventually
delivered in those centres (actual clinic birth rate). Thus, the contribution of the clinics to the
overall births in Amajuba District dropped from 24% in 1990 to
6% in 2012, accompanied by increased referrals from these care
centres to the hospital. A sharp increase in the referrals was
observed in 2000 (Fig. 3).
Fig. 3. Trends in clinic utilisation.
The mothers of 134 157 (84.4%)
of the 158 954 births received some form of antenatal
care (one or more visits), while the remaining 24 797 (15.6%)
received none. As depicted in Fig. 4, 5% of the pregnant women
who delivered in 1990 received no care, against 1.9% in 2012.
Booking rate before 20 weeks
generally remained low until early 2000. Hence, the antenatal
care bookings before 20 weeks more than doubled when 1990 was
compared with 2012 (13.5% and 30.5%, respectively).
Fig. 4. Trends in antenatal care; booking refers to the percentage of mothers booking before 20 weeks’ gestation.
Delivery and postdelivery events
Of the 158 954 deliveries, 136 065 (85.6%), 20 664 (13%) and 2 225 (1.4%) were in hospital, clinic and homes, respectively. The mode of delivery was normal vertex delivery in 138 131 cases (85.8%), caesarean section in 21 691 (13.5%) and assisted in 1 110 (0.7%).
The episiotomy rate rose steadily until the
late 1990s, when it began descending. The caesarean section rate
varied marginally between 12 and 14% from 1990 to 2007, after
which it rose to 19.7% in 2012 (Fig. 5). Also, from 2004, there
has been no reported case of ruptured uterus. The risk of
meconium aspiration rose steadily up until 2007, when it dropped
sharply. Perinatal asphyxia had been increasing from 2.1% in
1990 to 6.8% in 2007, but in 2007 this began a descent and
subsequently remained at values <5%.
Fig. 5. Trends in delivery and postdelivery events. (CSR = caesarean section rate; MAS = meconium aspiration syndrome.)
Risk of non-pregnancy-related infections
Although overall infections showed a
steady decline, syphilis showed an initial increase before
plummeting after 1995 (Fig. 6). At the beginning
of the PMTCT programme in 2003, only 7.3% of women attending
antenatal clinics tested positive for HIV. By 2012, the
percentage had increased to between 30 and 34%.
Fig. 6. Trends in peripartum infection.
While only 3% of eligible HIV-positive women
were on highly active ARV therapy as at 2008, the corresponding
figure in 2012 was 90%.
The current study indicated the need for continued efforts to use high-quality data derived from communities to monitor the state of obstetric and neonatal services in the communities.
Most births and deaths in SA occur in district hospitals, and, not infrequently, deaths result from substandard care. 3 , 5 , 13 Therefore, it is not surprising that in its quest for accelerated reduction in maternal and childhood deaths, the SA government implemented a series of quality improvement programmes to improve care in district hospitals. These strategies were monitored by two facility-based audits, namely the Perinatal Problem Identification Programme, and the Child Problem Identification Programme.5 Unfortunately, large studies to evaluate the trend in perinatal indicators in district hospitals are not readily available, and thus healthcare workers often do not have baseline data to refer to.
It is with this in mind that we undertook this study, in which perinatal indices in a typical district hospital and its catchment primary healthcare centres were documented and analysed for the period between 1990 and 2012. Since the data represent hospital, clinic and home births, it is reasonable to assume that they are representative of Amajuba District and can thus be used as a barometer to measure the state of maternal and neonatal health in this district.
The major strength of this study was its large sample size, access to a mostly non-referral sample and use of maternity data to evaluate services within the district.
The striking overall finding revealed the wave-like fluctuation in perinatal indices, with two peaks and troughs; the 1990s witnessed the first decline in SBR, PMR and MMR, followed by a rise in these indices until after 2005, when another decline ensued.
It is noteworthy that the initial worsening of perinatal indicators up until after 2005 coincided with the peak of the HIV/AIDS epidemic in SA,3 , 5 and the transition to better outcomes followed the intensification of the PMTCT programme and the widespread availability of ARVs to pregnant women and infants.9 , 14 Current reports emanating from SA reveal that after years of rising childhood15 and maternal mortality,13 , 16-18 there has been a dramatic decline in deaths in the last 5 years, and the turnaround may be ascribed to rapid scale-up measures for the PMTCT programme and expanded rollout of ARVs to infected mothers and infants.
There are several other possible reasons for improved maternal and newborn health markers in this current study, including better management of an underperforming health system that was caving in under the pressure of the then HIV epidemic,19 the consultant outreach programme,20 better ante-, peri- and postnatal care,10 improved ambulance services and thus a better referral system21 (which led to improved patient flow to the hospital from the clinics and much-reduced clinic deliveries), a concomitant increase in the caesarean section rate and the decline in perinatal asphyxia.
Furthermore, in this study, there was no recorded case of ruptured uterus in the health facilities since 2003. This finding attests to the fact that more women in Amajuba District now have access to emergency obstetric care. It is unlikely that other risk factors for ruptured uterus, such as contracted pelvis, inappropriate use of uterotonic drugs and scarred uterus, have substantially changed during the course of this study.
Another notable finding in this report was that there was a progressive decrease in births in the clinics, as manifested by a decline in both the number of labouring women seeking initial care in the clinics, and the overall contribution of the clinics to total births in the Amajuba District. While patients side-stepping the clinics for hospital births may denote a weakness in the primary healthcare system, this change in behaviour of the population may have contributed positively to the overall decline in deaths, as more mothers were offered caesarean section towards the latter part of this series.
The perinatal care index over the entire study period was much higher than what was expected.22 This seems to suggest that there is need for additional effort to improve the healthcare system and delivery within the district in spite of the apparent gains. However, averting further perinatal deaths will require knowledge of the major causes of neonatal and maternal deaths in Amajuba District, narrowing the gulf of socioeconomic quintiles in SA23 and holistic, synchronised healthcare. All these are beyond the scope of this study.
This study of perinatal indices in Amajuba District revealed that there has been a reversal of the worsening trend that occurred during the 1990s, which was largely ascribed to the effect of the HIV/AIDS epidemic. The turnaround is as a result of various factors, such as improvements in comprehensive obstetric and neonatal care, the PMTCT programme and the overall elevation of the quality of care in our facilities.
Acknowledgements. The authors hereby acknowledge the support of the medical, nursing and medical record staff of the maternity wing of Madadeni Hospital in the data collection.
1. Bhutta Z, Chopra M, Axelson H, et al. Countdown to 2015 decade report (2000-10): Taking stock of maternal, new-born, and child survival. Lancet 2010;375(9730):2032-2044. [http://dx.doi.org/10.1016/S0140-6736(10)60678-2]
2. World Health Organization/United Nations Children’s Fund. Countdown to 2015. Building a Future for Women and Children: The 2012 Report. Washington DC: World Health Organization/United Nations Children’s Fund, 2012.
3. Chopra M, Lawn JE, Sanders D, et al. Achieving the health millennium development, South Africa: Challenges and priorities. Lancet 2009:374(9694):1023-1031. [http://dx.doi.org/10.1016/S0140-6736(09)61122-3]
4. United Nations. The Millenium Development Goals Report 2011. New York: United Nations, 2011. http://www.undp.org/...home/librarypage/mdg/MDG_report_2011.html (accessed 19 December 2014).
5. Bradshaw D, Chopra M, Kerber K, et al. Every death counts: Use of mortality audit data for decision making to save the lives of mothers, babies and children in South Africa. Lancet 2008:371(9620):1294-1301. [http://dx.doi.org/10.1016/S0140-6736(08)60564-4]
6. Greenfield DH. Evaluation of the use of neonatal manual of perinatal education programme. Proceedings of the 7th World IAMANEH Conference 2000. Capetown, South Africa. http://www.rmchsa.org/wp-content/resources/resources_by_theme/ (accessed 19 December 2014).
7. Bergh AM, van Rooyen E, Pattison RC. Scaling up kangaroo mother care in South African educational facilities. Human Resour Health 2008:6:13. [http://dx.doi.org/10.1186/1478-4491-6-13]
8. Pattinson RC. On-site screening for syphilis: The time has come. S Afr Med J 1998:88(6 Suppl);780-781.
9. Department of Health. National strategic plan: HIV, AIDS and STIs. Pretoria: Department of Health, 2007.
10. Bondi FS, Adhikari M. Improved survival of non-ventilated very-low-birth-weight infants at Madadeni Hospital, KwaZulu-Natal. S Afr J CH 2007;1(1):10-13.
11. Pattinson RC, ed. Saving Babies 2008-2009: Seventh Report on Perinatal Care in South Africa. Pretoria: Tshepesa Press, 2011.
12. Tollman SM, Kahn K, Garenine M, Gear JSS. Reversal in mortality trends: Evidence from Agincourt field site, South Africa: 1992-1995. AIDS 1999;13(9):1091-1097.
13. Bradshaw D, Bourne D, Nannan N. What are the Leading Causes of Death Among South African Children? MRC Policy Brief No. 3, December 2003. Cape Town: Medical Research Countil, 2003.
14. Grimwood A, Fatti G, Mothibi E, Eley B, Jackson D. Progress of preventing mother-to-child transmission of HIV at primary healthcare facilities and district hospitals in three South African provinces. S Afr Med J 2012;102(2):81-83.
15. Kerber KJ, Lawn TE, Johnson LF, et al. South African child deaths 1990-2011: Have HIV services reversed the trend enough to meet the Millenium Development Goal 4? AIDS 2013;27(16):2637-2648. [http://dx.doi.org/10.1097/01.aids.0000432987.53271.40]
16. Wabili N, Chersich M, Zuma K, Bauw D, Goudge J, Dwane N. Equity in maternal health in South Africa: An analysis of health service in a national household survey. PLoS One 2013:8(9):e73864. [http://dx.doi.org/10.1371/journal.pone.0073864]
17. Garene M, Keih K, Collinson MA, Gómez-Olivé FX, Tollman S. Maternal mortality in rural South Africa: The impact of case definition on levels and trend. Int J Womens Health 2013;5:457-463. [http://dx.doi.org/10.2147/IJWH.S45983]
18. Gouz JP, Gulmezoglu AM, Vogel J, et al. Moving beyond essential interventions for reduction of maternal mortality (the WHO multicountry survey on maternal and newborn health): A cross-sectional study. Lancet 2013;381(9879):1747-1755. [http://dx.doi.org/10.1016/S0140-6736(13)60686-8]
19. Bateman C. Coming soon: Nowhere to hide for hospital managers. S Afr Med J 2001;101(5):294-296.
20. Graede B, MacKerrow NH. Outreach programme: Consultant visits to rural hospitals. Continuing Medical Education 2011;29(2):54-58.
21. Schoon MG. Impact of inter-facilty transport on maternal mortality in the free state province. S Afr Med J 2013;103(8):534-537. [http://dx.doi.org/10.7196/samj.6828]
22. Pattison RC. Introduction, methods and definition of the survey. In: Pattison RC, ed. Saving Babies: A Perinatal Care Survey of South Africa. Durban: Medical Research Council, 2000:1-7.
23. Victora CG, Barros AJD, Axelson H, et al. How changes in coverage affect equity in mother and child health interventions in 35 count down to 2015 countries: An analysis of national surveys. Lancet 2012;380(9848):1149-1156. [http://dx.doi.org/10.1016/S0140-6736(12)61427-5]
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